Katerina Papanikopoulou Research Group

Publications

Research Articles

2025

  1. Santambrogio A, Horne RI, Metrick MA II, Brotzakis ZF, Rinauro D, Vourkou E, Katerina Papanikolopoulou, Skoulakis EMC, Linse S, Caughey B, Vendruscolo M.
    Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay. bioRxiv, 2025.03.09.642189. doi: 10.1101/2025.03.09.642189

2024

  1. Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios Skoulakis, Katerina Papanikolopoulou.
    Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells 13(9):746.
  2. De Koninck Y, Alonso J, Bancelin S, Béïque JC, Bélanger E, Bouchard C, Canossa M, Chaniot J, Choquet D, Crochetière MÈ, Cui N, Danglot L, De Koninck P, Devor A, Ducros M, Getz AM, Haouat M, Hernández IC, Jowett N, Keramidis I, Larivière-Loiselle C, Lavoie-Cardinal F, MacGillavry HD, Malkoç A, Mancinelli M, Marquet P, Minderler S, Moreaud M, Nägerl UV, Katerina Papanikolopoulou, Paquet ME, Pavesi L, Perrais D, Sansonetti R, Thunemann M, Vignoli B, Yau J, Zaccaria C.
    Understanding the nervous system: lessons from Frontiers in Neurophotonics. Neurophotonics 11(1):014415.

2023

  1. Iason Keramidis, Martina Samiotaki, Romain Sansonetti, Johanna Alonso, Katerina Papanikolopoulou, Yves De Koninck.
    Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology. bioRxiv, 2023.09.12.557365. doi: 10.1101/2023.09.12.557365
  2. Vasiliki Papadaki, Zoi Erpapazoglou, Maria Kokkori, Malgorzata Rogalska, Myrto Potiri, Andrada Birladeanu, Eleni Tsakiri, Hassan Ashktorab, Duane Smoot, Katerina Papanikolopoulou, Martina Samiotaki, Panagiota Kafasla.
    IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing. NAR Cancer 5(3):zcad046.

 

2022

  1. Erina Vourkou, Vassilis Paspaliaris, Anna Bourouliti, Maria-Christina Zerva, Engie Prifti, Katerina Papanikolopoulou, Efthimios Skoulakis.
    Differential effects of human Tau isoforms to neuronal dysfunction and toxicity in the Drosophila CNS. Int J Mol Sci 23:12985.
  2. Evangelos Karatzas, Mikaela Koutrouli, Fotis Baltoumas, Katerina Papanikolopoulou, Costas Bouyioukos, Georgios A Pavlopoulos.
    The network makeup artist (NORMA-2.0): Distinguishing annotated groups in a network using innovative layout strategies. Bioinformatics Advances. doi:10.1093/bioadv/vbac036
  3. Engie Prifti, Eleni N Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M C Skoulakis, Katerina Papanikolopoulou.
    Mical modulates Tau toxicity via cysteine oxidation in vivo. Acta Neuropathol Commun 10:44.
  4. Chrysoula Kokotidou, Fani Tsitouroudi, Georgios Nistikakis, Marita Vasila, Katerina Papanikolopoulou, Androniki Kretsovali, Anna Mitraki.
    Adenovirus Fibers as Ultra-Stable Vehicles for Intracellular Nanoparticle and Protein Delivery. Biomolecules 12:308.

2021

  1. Engie Prifti, Eleni Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Katerina Papanikolopoulou.
    The two Cysteines of Tau protein are functionally distinct and contribute differentially to its pathogenicity in vivo. J Neurosci 41, 797–810.

2020

  1. Iason Keramidis, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios Skoulakis.
    Functional interactions of Tau phosphorylation sites that mediate toxicity and deficient learning in Drosophila melanogaster. Front Mol Neurosci 13:569520.
  2. Mikaela Koutrouli, Evangelos Karatzas, Katerina Papanikolopoulou, Georgios A. Pavlopoulos.
    NORMA-The network makeup artist: a web tool for network annotation visualization. Genomics Proteomics Bioinformatics. doi:10.1016/j.gpb.2021.02.005.

2019

  1. Ilianna Roussou, Katerina Papanikolopoulou, Charalambos Savakis, Efthimios Skoulakis.
    Drosophila Bruton’s Tyrosine Kinase regulates habituation latency and facilitation in distinct mushroom body neurons. J Neurosci 39, 8730–8743.
  2. Katerina Papanikolopoulou, Jean Gouzi, Ilianna Roussou, Martina Samiotaki, Efthimios Skoulakis.
    Drosophila Tau negatively regulates translation and olfactory long-term memory, but facilitates foot shock habituation and cytoskeletal homeostasis. J Neurosci 39, 8315–8329.
  3. Kadas Dimitrios, Papanikolopoulou Katerina, Xirou Sofia, Consoulas Christos, Skoulakis Efthimios.
    Human Tau isoform-specific presynaptic deficits in a Drosophila Central Nervous System circuit. Neurobiol Dis 124, 311–321.

2018

  1. Katerina Papanikolopoulou, Sofia Grammenoudi, Martina Samiotaki, Efthimios Skoulakis.
    Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo. Hum Mol Genet 27, 2244–2261.

2017

  1. A. Prigkipaki, K. Papanikolopoulou, E. Mossou, E.P. Mitchell, V.T. Forsyth, A. Selimis, A. Ranella, A. Mitraki.
    Laser processing of protein films as a method for accomplishment of cell patterning at the microscale. Biofabrication 9, 045004.

2015

  1. Katerina Papanikolopoulou, Efthimios Skoulakis.
    Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila. Human Molecular Genetics 24, 2065–2077. (co-corresponding author)

2010

  1. Katerina Papanikolopoulou, Stelios Kosmidis, Sofia Grammenoudi, Efthimios Skoulakis.
    Phosphorylation differentiates Tau-dependent neuronal toxicity and dysfunction. Biochemical Society Transactions 38, 981–987.
  2. Stelios Kosmidis, Sofia Grammenoudi, Katerina Papanikolopoulou, Efthimios Skoulakis.
    Phosphorylation mediates differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila. Journal of Neuroscience 30, 464–477.

2008

  1. Katerina Papanikolopoulou, Ishara Mills-Henry, Shannon L. Thol, Yongting Wang, Abby A.R. Gross, Daniel A. Kirschner, Sean M. Decatur, Jonathan King.
    Formation of amyloid fibrils in vitro by Human γD protein and its isolated domains. Molecular Vision 14, 81–89.

2005

  1. Katerina Papanikolopoulou, Vincent Forge, Guy Schoehn, Christian Riekel, Jean-François Hernandez, Rob W. H. Ruigrok, Trevor V. Forsyth, Anna Mitraki.
    Amyloid fibril formation from sequences of a natural β-structured fibrous protein, the adenovirus fibre. Journal of Biological Chemistry 280, 2481–2490.
  2. Katerina Papanikolopoulou, Vincent Forge, Guy Schoehn, Christian Riekel, Jean-François Hernandez, Rob W. H. Ruigrok, Trevor V. Forsyth, Anna Mitraki.
    Amyloid fibrils formed by peptide sequences from a natural β-structured fibrous protein, the fibre of adenovirus. Fibre Diffraction Review 13, 43–47.
  3. Haris Retsos, Katerina Papanikolopoulou, Claude Fillipini, Christian Riekel, Kenncorwin H. Gardner, V. Trevor Forsyth, Anna Mitraki.
    Amyloid character of self-assembling proteins based on adenovirus fibre shaft sequences: a fibrous biomaterial revisited. NanoBiotechnology 1, 219–226.

2004

  1. Katerina Papanikolopoulou, Susana Teixeira, Hassan Belrhali, V. Trevor Forsyth, Anna Mitraki, Mark J. van Raaij.
    Adenovirus fibre shaft sequences fold into the native triple beta-spiral fold when N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif. Journal of Molecular Biology 342, 219–227.
  2. Katerina Papanikolopoulou, Vincent Forge, Pierrette Goeltz, Anna Mitraki.
    Formation of highly stable chimeric trimers by fusion of an adenovirus fibre shaft fragment with the foldon domain of bacteriophage T4 fibritin. Journal of Biological Chemistry 279, 8991–8998.

Book Chapters & Reviews

2025

  1. Katerina Papanikolopoulou, Eleni M. Georganta, Efthimios M. C. Skoulakis.
    Memory with a little H₂O₂ help from astrocyte friends. Nature Metabolism 7, 236–238.

2024

  1. Maria Tsekrekou, Maria Giannakou, Katerina Papanikolopoulou, Georgios Skretas.
    Protein aggregation and therapeutic strategies in SOD1- and TDP-43-linked ALS. Frontiers in Molecular Biosciences 11, 1–27.

2020

  1. Katerina Papanikolopoulou, Efthimios Skoulakis.
    Altered proteostasis in neurodegenerative Tauopathies. Advances in Experimental Medicine and Biology 1233, 177–194.

2019

  1. Katerina Papanikolopoulou, Amrit Mudher, Efthimios Skoulakis.
    An assessment of the translational relevance of Drosophila in drug discovery. Expert Opinion on Drug Discovery 14, 122–133.

2011

  1. Katerina Papanikolopoulou, Efthimios Skoulakis.
    The Power and Richness of Modelling Tauopathies in Drosophila. Molecular Neurobiology 44, 122–133.

2008

  1. Katerina Papanikolopoulou, Mark J. van Raaij, Anna Mitraki.
    Creation of hybrid nanorods from sequences of natural trimeric fibrous proteins by use of the fibritin trimerization motif. Methods in Molecular Biology 474, 15–33.

2006

  1. Anna Mitraki, Katerina Papanikolopoulou, Mark van Raaij.
    Natural triple beta-spiral folds. Advances in Protein Chemistry 73, 97–124.