MicroCT Imaging

Advanced micro-CT imaging services and support are available at BSRC Fleming for research involving ex vivo analysis of selected tissues derived from small animals (mineralized biomaterials, grafts, implants, composites etc).

The recently acquired SkyScan1172 high-resolution micro-CT delivers high quality images and can be used by researchers for X-ray scans of selected regions of small animals followed by 3D visualization. Quantitative bone density and bone micro-architecture are a few of the available services provided.

The services provided include:

The micro-CT scanner is co-financed by the European Regional Development Fund, the European Social Fund and Greece’s NSRF 2007-2013, under programs Innate Fibroblast (ERC-06) and InfrafrontierGR (MIS 423575).

Publications:

1. Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G. Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities. Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. [Pubmed]
2. Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT. Club cells form lung adenocarcinomas and maintain the alveoli of adult mice. 2019 Elife May 29;8. pii: e45571. doi: 10.7554/eLife.45571 [PubMed]
3. Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M. (2019) A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol. 2019 May 13. doi: 10.1038/s41556-019-0324-3. [PubMed]
4. Papadaki M, Rinotas V, Violitzi F, Thireou T, Panayotou G, Samiotaki M, Douni E. (2019) New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis. Front Immunol. 2019 Feb 5;10:97. doi: 10.3389/fimmu.2019.00097 [PubMed]
5. Armaka M, Ospelt C, Pasparakis M, Kollias G. 2018 The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. Nat Commun. 9(1):618. [PubMed]
6. Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G. 2017 Sci Rep. 7(1):2397. [PubMed]