Vasso Kostourou Research Group

Romani P, Benedetti G, Cusan M, Arboit M, Cirillo C, Wu X, Rouni G, Kostourou V, Aragona M, Giampietro C, Grumati P, Martello G, Dupont S. Mitochondrial mechanotransduction through MIEF1 coordinates the nuclear response to forces. Nat Cell Biol. 2024 Oct 21. doi: 10.1038/s41556-024-01527-3. Epub ahead of print. PMID: 39433949.

Kostourou V, Goult BT, Ambriović-Ristov A. Editorial: Integrin adhesion receptors in health and disease. Front Cell Dev Biol. 2023 Feb 14;11:1149920. doi: 10.3389/fcell.2023.1149920. PMID: 36866274; PMCID: PMC9971948.

Valaris, S., Kostourou, V. (2023). Cell–Extracellular Matrix Adhesions in Vascular Endothelium. In: Papadimitriou, E., Mikelis, C.M. (eds) Matrix Pathobiology and Angiogenesis. Biology of Extracellular Matrix, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-031-19616-4_7

Arapatzi C, Rouni G, Kostourou V. Vascular cell-matrix adhesion in development and cancer. Int J Dev Biol. 2022;66(1-2-3):103-113. doi: 10.1387/ijdb.210204vk. PMID: 34881799.

Gargani S, Lourou N, Arapatzi C, Tzanos D, Saridaki M, Dushku E, Chatzimike M, Sidiropoulos ND, Andreadou M, Ntafis V, Hatzis P, Kostourou V, Kontoyiannis DL. Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages. Front Immunol. 2022 Feb 11;13:752215. doi: 10.3389/fimmu.2022.752215. PMID: 35222366; PMCID: PMC8873154.

Nikolopoulou PA, Koufaki MA, Kostourou V. The Adhesome Network: Key Components Shaping the Tumour Stroma. Cancers (Basel). 2021 Jan 30;13(3):525. doi: 10.3390/cancers13030525. PMID: 33573141; PMCID: PMC7866493.

Daras G, Rigas S, Alatzas A, Samiotaki M, Chatzopoulos D, Tsitsekian D, Papadaki V, Templalexis D, Banilas G, Athanasiadou AM, Kostourou V, Panayotou G, Hatzopoulos P. LEFKOTHEA Regulates Nuclear and Chloroplast mRNA Splicing in Plants. Dev Cell. 2019 Sep 23;50(6):767-779.e7. doi: 10.1016/j.devcel.2019.07.024. Epub 2019 Aug 22. PMID: 31447263.

Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM. Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861. Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12. PMID: 31189647.

Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM. Endothelial FAK is required for tumour angiogenesis. EMBO Mol Med. 2016 Oct 4;8(10):1229. doi: 10.15252/emmm.201606907. Erratum for: EMBO Mol Med. 2010 Dec;2(12):516-28. doi: 10.1002/emmm.201000106. PMID: 27702771; PMCID: PMC5048370.

Kamber M, Papalazarou V, Rouni G, Papageorgopoulou E, Papalois A, Kostourou V. 2015, "Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice", Front Physiol. , 2015 Jun 9;6:170. , doi: 10.3389/fphys.2015.00170. eCollection 2015. [PubMed].

Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B, Hodivala-Dilke K. 2014, "Generation of point-mutant FAK knockin mice", Genesis. , 2014 Nov;52(11) 907-15. doi: 10.1002/dvg.22823. Epub 2014 Sep 30. [PubMed].

Kotsinas A, Papanagnou P, Evangelou K, Trigas GC, Kostourou V, Townsend P, Gorgoulis VG. 2014, "ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.", Front Genet. , 2014 Jul 22; 5:236. doi: 10.3389/fgene.2014.00236. eCollection 2014. [PubMed].

Kostourou V, Papalazarou V. 2014, "Non-collagenous ECM proteins in blood vessel morphogenesis and cancer.", Biochim Biophys Acta. , 2014 Aug; 1840(8):2403-13. doi: 10.1016/j.bbagen.2014.02.018. Epub 2014 Feb 24. [PubMed].

Kostourou V* , Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K. 2013, "FAK-heterozygous mice display enhanced tumour angiogenesis.", Nat Commun. , 2013;, 4:2020. doi: 10.1038/ncomms3020. [PubMed].
*(corresponding author)
Press release from Nature Publishing Group office and highlight in Nature.com web page.

Ikonomou G, Kostourou V , Shirasawa S, Sasazuki T, Samiotaki M, Panayotou G. 2012, "Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.", J Proteomics., 2012 Sep 18;, 75(17):5356-69. doi: 10.1016/j.jprot.2012.06.038. Epub 2012 Jul 16. [PubMed].

Kostourou V , Cartwright JE, Johnstone AP, Boult JK, Cullis ER, Whitley G, Robinson SP. 2010, "The role of tumour-derived iNOS in tumour progression and angiogenesis.", Br J Cancer. , 2011 Jan 4;, 104(1):83-90. Epub 2010 Dec 7. [PubMed].

Monkley SJ, Kostourou V , Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR. 2010, "Endothelial cell talin1 is essential for embryonic angiogenesis.", Dev Biol. , 2011 Jan 15;, 349(2):494-502. Epub 2010 Nov 26. [PubMed].

Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V , Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM. 2010, "Endothelial FAK is required for tumour angiogenesis.", EMBO Mol Med. , 2010 Dec;, 2(12):516-28. [PubMed].

da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM. 2010, "Endothelial {alpha}3{beta}1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF.", Am J Pathol. , 2010 Jul 16. , [Epub ahead of print] [PubMed].

Kalogeropoulou M, Voulgari A, Kostourou V, Sandaltzopoulos R, Dikstein R, Davidson I, Tora L, Pintzas A. 2010, "TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.", Mol Cancer Res. , 2010 Apr; , 8(4):554-68. Epub 2010 Mar 30. [PubMed].

Germain M, De Arcangelis A, Robinson SD, Baker M, Tavora B, D'Amico G, Silva R, Kostourou V, Reynolds LE, Watson A, Jones JL, Georges-Labouesse E, Hodivala-Dilke K. 2010, "Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.", J Pathol. , 2010 Feb; , 220(3):370-81. [PubMed].

D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V,Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM. 2009, "Regulation of lymphatic-blood vessel separation by endothelial Rac1.", Development. , 2009 Dec;136(23):4043-53. , Erratum in: Development. 2010 Jan;137(2):359. [PubMed].

Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF, Hodivala-Dilke KM. 2009, "Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.", J Biol Chem. 2, 2009 Dec 4; , 84(49):33966-81. Epub 2009 Oct 16. [PubMed].

Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM. 2009, "Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.", Nat Med. , 2009 Apr;15(4): , 392-400. Epub 2009 Mar 22. [PubMed].

Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, Fruttiger M. 2008, "Efficient, inducible Cre-recombinase activation in vascular endothelium.", Genesis. , 2008 Feb;, 46(2):74-80. [PubMed].

Kostourou V, Troy H, Murray JF, Cullis ER, Whitley GS, Griffiths JR, Robinson SP. 2004, "Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.", Neoplasia. , 2004 Jul-Aug;, 6(4):401-11. [PubMed].

Takamiya K Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler PJ, Huganir RL, Adams RH. 2004, "A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.", Nat Genet. , 2004 Feb;36(2):, 172-7. Epub 2004 Jan 18. [PubMed].

Kostourou V, Robinson SP, Whitley GS, Griffiths JR. 2003, "Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.", Cancer Res. , 2003 Aug 15;, 63(16):4960-6. [PubMed].

Kostourou V, Robinson SP, Cartwright JE, Whitley GS. 2002, "Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis.", Br J Cancer. , 2002 Sep 9;, 87(6):673-80. [PubMed].

Thiru A, Hodach M, Eloranta JJ, Kostourou V, Weinzierl RO, Matthews S. 1999, "RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes.", J Mol Biol. , 1999 Apr 9;, 287(4):753-60. [PubMed].