Dimitris Kontoyiannis Research Group

Pallavi Subramanian, Sofia Gargani, Alessandra Palladini, Margarita Chatzimike, Michal Grzybek, Mirko Peitzsch, Anastasios D Papanastasiou, Iryna Pyrina, Vasileios Ntafis, Bettina Gercken, Mathias Lesche, Andreas Petzold, Anupam Sinha, Marina Nati, Veera Raghavan Thangapandi, Ioannis Kourtzelis, Margarita Andreadou, Anke Witt, Andreas Dahl, Ralph Burkhardt, Robert Haase, António Miguel de Jesus Domingues, Ian Henry, Nicola Zamboni, Peter Mirtschink, Kyoung-Jin Chung, Jochen Hampe, Ünal Coskun, Dimitris L Kontoyiannis, Triantafyllos Chavakis. 2021, "The RNA binding protein HuR is a gatekeeper of liver homeostasis.", Hepatology., 2021 Sep 14. doi: 10.1002/hep.32153. Online ahead of print. [PubMed].

Birladeanu AM, Rogalska M, Potiri M, Papadaki V, Andreadou M, Dimitris L Kontoyiannis, Lewis JD, Erpapazoglou Z, Kafasla P. 2021, "The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.", Oncogene. , 2021 Sep; 40(36):5518-5532. doi: 10.1038/s41388-021-01963-7. Epub 2021 Jul 23. [PubMed].

Ehlich H, Cater HL, Flenniken AM, Goncalves Da Cruz I, Mura AM, Ntafis V, Raess M, Selloum M, Stoeger C, Suchanova S, Vuolteenaho R, Brown SDM, Hérault Y, Hinttala R, Hrabě de Angelis M, Kollias G, Dimitris L Kontoyiannis, Malissen B, McKerlie C, Sedláček R, Wells SE, Zarubica A, Rozman J, Sorg T. 2021, "INFRAFRONTIER quality principles in systemic phenotyping.", Mamm Genome, 2021 Jul 30. doi: 10.1007/s00335-021-09892-2. Online ahead of print. [PubMed].

Sandip Mukherjee, Ritesh Kumar, Elviche Tsakem Lenou, Venkatesha Basrur, Dimitris L. Kontoyiannis, Fotis Ioakeimidis, George Mosialos, Arianne L. Theiss, Richard A. Flavell & K. Venuprasad. 2020, "Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.", Nature Immunology , (2020) doi: 10.1038/s41590-020-0681-x [Nature].

Gagliano T, Shah K, Gargani S, Lao L, Alsaleem M, Chen J, Ntafis V, Huang P, Ditsiou A, Vella V, Yadav K, Bienkowska K, Bresciani G, Kang K, Li L, Carter P, Benstead-Hume G, O'Hanlon T, Dean M, Pearl FM, Lee SC, Rakha EA, Green AR, Kontoyiannis DL, Song E, Stebbing J, Giamas G. 2020, "PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression.", J Clin Invest. , 2020 May 11. pii: 128313. doi: 10.1172/JCI128313. [Epub ahead of print] [PubMed].

Lourou N, Gavriilidis M, Kontoyiannis DL, . 2019, "Lessons from studying the AU-rich elements in chronic inflammation and autoimmunity.", J Autoimmun. , 2019 Nov; 104:102334. doi: 10.1016/j.jaut.2019.102334. Epub 2019 Oct 8. Review [PubMed].

Janice Sánchez B, Tremblay AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer PL, Phillips BL, Vest KE, Corbett AH, Kontoyiannis DL, Hussain SNA, Hastings KEM, Di Marco S, Gallouzi IE. 2019, "Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy.", Nat Commun. , 2019 Sep 13; 10(1):4171. doi: 10.1038/s41467-019-12186-6. [PubMed].

Christodoulou-Vafeiadou E, Ioakeimidis F, Andreadou M, Giagkas G, Stamatakis G, Reczko M, Samiotaki M, Papanastasiou AD, Karakasiliotis I, Kontoyiannis DL. 2018, "Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation", Front. Immunol. , 9:2732. . doi: 10.3389/fimmu.2018.02732. eCollection 2018. [PubMed].

Kontoyiannis DL. 2018, "An RNA checkpoint that keeps immunological memory at bay", Nat Immunol. , 2018 Jul 9. doi: 10.1038/s41590-018-0168-1. [Epub ahead of print] [PubMed].

Karatzas DN, Xanthopoulos K, Kotantaki P, Pseftogas A, Teliousis K, Hatzivassiliou EG, Kontoyiannis DL, Poutahidis T, Mosialos G. 2016, "Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report.", Cell Oncol (Dordr). , 2016 Apr 4. [Epub ahead of print] [PubMed].

Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M. 2015, "The RNA-binding protein HuR is essential for the B cell antibody response.", Nat Immunol. , 2015 Feb 23. doi: 10.1038/ni.3115. [Epub ahead of print] [PubMed].

Skliris A, Papadaki O, Kafasla P, Karakasiliotis I, Hazapis O, Reczko M, Grammenoudi S, Bauer J, Kontoyiannis DL. 2014, "Neuroprotection requires the functions of the RNA-binding protein HuR", Cell Death Differ, 2014 Oct 10. doi: 10.1038/cdd.2014.158. [Epub ahead of print] [PubMed].

Liu L, Christodoulou-Vafeiadou E, Rao JN, Zou T, Xiao L, Kyoung Chung H, Yang H, Gorospe M, Kontoyiannis D , Wang JY. 2014, "RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway.", Mol Biol Cell. , 2014 Aug 27. pii: mbc.E14-03-0853. [Epub ahead of print] [PubMed].

Kraushar ML, Thompson K, Wijeratne HR, Viljetic B, Sakers K, Marson JW, Kontoyiannis DL , Buyske S, Hart RP, Rasin MR. 2014, "Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.", Proc Natl Acad Sci U S A. , 2014 Aug 25. pii: 201408305. [Epub ahead of print] [PubMed].

Kafasla P, Skliris A, Kontoyiannis DL. 2014, "Post-transcriptional coordination of immunological responses by RNA-binding proteins.", Nat Immunol., 2014 May 19; 15(6):492-502. doi: 10.1038/ni.2884. [PubMed].

Kawagishi H, Hashimoto M, Nakamura H, Tsugawa T, Watanabe A, Kontoyiannis DL , Sugimoto M. 2013, "HuR Maintains a Replicative Life Span by Repressing the ARF Tumor Suppressor.", Mol Cell Biol. , 2013 May; , 33(10):1886-900. doi: 10.1128/MCB.01277-12. Epub 2013 Mar 18. [PubMed].

Kafasla P, Karakasiliotis I, Kontoyiannis DL 2012, "Decoding the functions of post-transcriptional regulators in the determination of inflammatory states: focus on macrophage activation.", Wiley Interdiscip Rev Syst Biol Med. , 2012 Jul 3. , doi: 10.1002/wsbm.1179. [Epub ahead of print] [PubMed].

Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis DL 2012, "Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.", J Clin Invest. , 2011 Dec 27. pii: 45021. doi: 10.1172/JCI45021. , [Epub ahead of print] [PubMed], [Article], [Commentary] .

Karakasiliotis I, Kontoyiannis DL 2011, "ASCertaining cytoskeletal rearrangements in antigen presentation and migration.", Nat Immunol. , 2011 Sep 20;, 12(10):923-5. doi: 10.1038/ni.2114 [PubMed].

Chi MN, Auriol J, Jégou B, Kontoyiannis DL , Turner JM, de Rooij DG, Morello D. 2011, "The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.", Mol Biol Cell. , 2011 Aug 15;, 22(16):2875-85. Epub 2011 Jul 7. [PubMed].

Sgantzis A., Yiakouvaki A., Remboutsika E., Kontoyiannis DL 2011, "HuR controls lung branching morphogenesis and mesenchymal FGF networks.", Dev Biol. 2011 , [in press], [PubMed].

García-Domínguez DJ, Morello D, Cisneros E, Kontoyiannis DL , Frade JM. 2011, "Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.", Mol Biol Cell. , 2011 Feb 23, [PubMed].

Tsagaratou A, Kontoyiannis DL , Mosialos G. 2011, "Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.", PLoS One. , 2011 Jan 20;, 6(1):e16397. [PubMed].

Tsagaratou A, Trompouki E, Grammenoudi S, Kontoyiannis DL ,Mosialos G. 2010, "Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.", J Immunol. , 2010 Aug 15;, 185(4):2032-43. Epub 2010 Jul 19 [PubMed].

Stamou P, Kontoyiannis DL 2010, "Posttranscriptional Regulation of TNF mRNA: A Paradigm of Signal-Dependent mRNA Utilization and Its Relevance to Pathology.", Curr Dir Autoimmun., 2010;11:61-79. , Epub 2010 Feb 18. [PubMed].

Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL , Remboutsika E, Aidinis V 2010, "ATX expression and LPA signalling are vital for the development of the nervous system.", Dev Biol., Jan 13. , Epub ahead of print [PubMed].

Olympia Papadaki, Stavros Milatos, Sofia Grammenoudi, Neelanjan Mukherjee, Jack D. Keene and Dimitris L. Kontoyiannis, 2009, "Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR", Journal of Immunology, 182: 6779-6788. .[Pubmed]

Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, Harokopos V, Aidinis V, Hemberger M, Kontoyiannis DL., 2009, "The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development.", Mol Cell Biol., May 29 , 10:2762-76 [PubMed].

Eirini Trompouki, Ageliki Tsagaratou, Stylianos K Kosmidis, Pascal Dolle, Jun Qian, Dimitris L Kontoyiannis, Wellington V. Cardoso and George Mosialos, 2009, "Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation ", Neoplasia, Volume 11, Issue 5 [Abstract].

Apostolaki M, Manoloukos M, Roulis M, Wurbel MA, Müller W, Papadakis KA, Kontoyiannis DL., Malissen B, Kollias G, 2008, "Role of beta7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease", Gastroenterology, 134(7), 2025-35 [PubMed].

Maria Armaka, Maria Apostolaki, Peggy Jacques, Dimitris L Kontoyiannis, Dirk Elewaut, Kollias G, 2008, "Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases", J Exp Med, 205(2), 331-7 [PubMed].

Douni E, Armaka M, Kontoyiannis DL. Kollias G., 2007, "Functional genetic and genomic analysis of modeled arthritis", Adv Exp Med Biol., 2007, 602:33-42 [PubMed - in process].

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL. Zouberakis M, Kollias G; the Mugen NoE consortium.., 2007, "MUGEN mouse database; Animal models of human immunological diseases", Nucleic Acids Res., 2007 Oct 11, Epub ahead of print [PubMed].

Katsanou V, Dimitriou M, Kontoyiannis DL., 2007, "Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics.", Ernst Schering Found Symp Proc., 2006, 4:37-57 [PubMed].

Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A, Douni E, Blackshear PJ, Kontoyiannis DL., Kollias G., 2006, "Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.", Eur J Immunol., 2006 Oct, 36(10):2768-80 [PubMed].

Katsanou V., Papadaki O., Milatos S., Blackshear P., Anderson P., Kollias G. and , Kontoyiannis D. , 2005, "HuR as a Negative Posttranscriptional Modulator in Inflammation", Mol. Cell., 19, 777-789 [ Mol. Cell].

Alexopoulou L., Kontoyiannis D., 2005, "Contribution of microbial-associated molecules in innate mucosal responses", CMLS, Cell.Mol.Life Sci., 62, 1349-58 [PubMed].

Staelens J., Puimege L., Mahieu T., Pynaert G., Hochepied T., Vandenabeele A., Grooten J., Kontoyiannis D., Van Roy F., Kollias G., Libert C., 2004, "Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders", Mamm. Genome., 15, 537-543 [PubMed].

Kontoyiannis D., 2003, "Cells, genes and pathways in modeled TNF induced IBD", Arch. Hellenic Med., 20, 54-57.

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, "Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease", J. Exp. Med., 196, 1563-1574 [PubMed].

Kollias G., Kontoyiannis D., 2002, "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments", Cytokine Growth Factor Rev., 13, 315-321 [PubMed].

Kollias G., Kontoyiannis D., Douni E., Kassiotis G., 2002, "The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies", Curr. Dir. Autoimmun., 5, 30-50 [PubMed].

Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H. D., Holtmann H., Kollias G., Gaestel M., 2002, "MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels", J. Biol. Chem., 277, 3065-3068 [PubMed].

Kontoyiannis D., Kotlyarov A., Carballo E., Alexopoulou L., Blackshear P. J., Gaestel M., Davis R., Flavell R., Kollias G., 2001, "Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology", EMBO J., 20, 3760-3770 [PubMed].

Dumitru C. D., Ceci J. D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J. H., Patriotis C., Jenkins N. A., Copeland N. G., Kollias G., Tsichlis P. N., 2000, "TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway", Cell, 103, 1071-1083 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Fibroblast biology. Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?", Arthritis Res., 2, 342-343 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor", Eur. J. Immunol., 30, 2038-2047 [PubMed].

Iyer S., Kontoyiannis D., Chevrier D., Woo J., Mori N., Cornejo M., Kollias G., Buelow R., 2000, "Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide", J. Biol. Chem., 275, 17051-17057 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Ann. Rheum. Dis., 58, 132-139 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Immunol. Rev., 169, 175-194 [PubMed].

Kontoyiannis D., Pasparakis M., Pizarro T. T., Cominelli F., Kollias G., 1999, "Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies", Immunity, 10, 387-398 [PubMed].

Plumier J. C., Krueger A. M., Currie R. W., Kontoyiannis D., Kollias G., Pagoulatos G. N., 1997, "Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury", Cell Stress Chaperones, 2, 162-167 [PubMed].

Probert L., Akassoglou K., Alexopoulou L., Douni E., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Kollias G., 1996, "Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice", J. Leukoc. Biol., 59, 518-525 [PubMed].

Angelidis C. E., Nova C., Lazaridis I., Kontoyiannis D., Kollias G., Pagoulatos G. N., 1996, "Overexpression of HSP70 in transgenic mice results in increased cell thermotolerance", Transgenics, 2, 111-117.

Douni E., Akassoglou K., Alexopoulou L., Georgopoulos S., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Probert L., Kollias G., 1995, "Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis", J. Inflamm., 47, 27-38 [PubMed].