PubMed – Google Scholar
2024
2024, "Identification of two novel chemical classes of Autotaxin (ATX) inhibitors using Enalos Asclepios KNIME nodes.", Bioorg Med Chem Lett., 2024 May 1; 103:129690 [PubMed].
2024, "L-Dopa decarboxylase modulates autophagy in hepatocytes and is implicated in dengue virus-caused inhibition of autophagy completion. ", Biochim Biophys Acta Mol Cell Res., 2024 Jan; 1871(1):119602. [PubMed].
2023, "Bioactive signaling lipids as drivers of chronic liver diseases. Bioactive signaling lipids as drivers of chronic liver diseases.", J Hepatol., 2024 Jan: ;80(1):140-154. [PubMed].
2023
2023, "Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis.", Respir Res., 24(1):279. [PubMed].
2023, "Increased Levels of Galectin-3 in Critical COVID-19", Int J Mol Sci., 2023 Oct 31; 24(21):15833. [PubMed].
2023, "N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity.", J Med Chem., 2023 Oct 26; 66(20):14357-14376. [PubMed].
2023, "SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis", Nat Commun., 2023 Sep 21; 14(1):5882. [PubMed].
2023, "Increased lipocalin-2 expression in pulmonary inflammation and fibrosis.", Front Med., 2023 Sep 7; 10:1195501. [PubMed].
2023, "The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer.", Int J Mol Sci., May 5; 24(9):8325. [PubMed].
2023, "Αn explainable machine learning-driven proposal of pulmonary fibrosis biomarkers.", Comput Struct Biotechnol J., 2023; 21:2305-2315 [PubMed].
2023, "SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.", Diagnostics 2023, 13 (6), 1166. [PubMed].
2023, ""Hit" to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors.", Eur J Med Chem., 2023 Mar 5; 249:115130. [PubMed].
2023, "Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.", Cells., 2023 Feb 3; 12(3):511. [PubMed].
2022
2022, "Autotaxin in Breast Cancer: Role, Epigenetic Regulation and Clinical Implications.", Cancers., 2022 Nov 4; 14(21):5437 [PubMed].
2022, "Autotaxin Has a Negative Role in Systemic Inflammation", Int J Mol Sci., 2022; 23(14):7920 [PubMed].
2022, "Autotaxin Activity in Chronic Subdural Hematoma: A Prospective Clinical Study", Diagnostics., 2022; 12(8):1865 [PubMed].
2022, "Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells", Int J Mol Sci., 2022 Jul 5;, 23(13):7452 [PubMed].
2022, "ENPP2 Promoter Methylation Correlates with Decreased Gene Expression in Breast Cancer: Implementation as a Liquid Biopsy Biomarker", Int J Mol Sci., 2022 Mar 28; , 23(7):3717. [PubMed].
2022, "ENPP2 Increases Atherosclerosis in Female and Male Mice.", Arterioscler Thromb Vasc Biol., 2022 Jun 16 , [PubMed].
2022, "Obesity Reshapes the Microbial Population Structure along the Gut-Liver-Lung Axis in Mice", Biomedicines., 2022 Feb 19; 10(2):494 [PubMed].
2021
2021, "Collagen 1a1 Expression by Airway Macrophages Increases In Fibrotic ILDs and Is Associated With FVC Decline and Increased Mortality", Front Immunol., 2021 Nov 17; 12:645548. [PubMed].
2021, "ENPP2 Methylation in Health and Cancer", Int J Mol Sci., 2021 Nov 4; 22(21):11958 [PubMed].
2021, "Fibromine is a multi-omics database and mining tool for target discovery in pulmonary fibrosis", Sci Rep., 2021 Nov 5; 11(1):21712 [PubMed].
2021, "Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.", Front Immunol., 2021 Oct 4; 12:687397 [PubMed].
2021, "Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells.", Int J Mol Sci., 2021 Sep 16; 22(18):10006. [PubMed].
2021, "Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation.", Mucosal Immunol., 2021 Sep; 14(5):1160-1171 [PubMed].
2021, "Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform.", PLoS One., 2021 Jun 29; 16(6):e0253458. [PubMed].
2021, "Systems biology reveals key tissue-specific metabolic and transcriptional signatures involved in the response of Medicago truncatula plant genotypes to salt stress.", Comput Struct Biotechnol J., 2021 Apr 8; 19:2133-2147 [PubMed].
2021, "A role for bronchial epithelial autotaxin in ventilator-induced lung injury.", Intensive Care Med Exp., 2021 Mar 29; 9(1):12 [PubMed].
2021, "Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy", Cell Rep., 2021 Mar 2; 34(9):108809. [PubMed].
2021, "Advances in de Novo Drug Design: From Conventional to Machine Learning Methods", Int J Mol Sci, 2021 Feb 7; 22(4):1676. [PubMed].
2021, "Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care.", Curr Opin Pharmacol., 2021 Feb 5; 57:71-80 [PubMed].
2020, "MAP3K8 Regulates Cox-2-Mediated Prostaglandin E 2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis.", J Immunol, 2021 Feb 1; 206(3):607-620. [PubMed].
2020
2020, "Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors.", Int J Mol Sci., 2020 Sep 23; 21(19):7002. [PubMed].
2020, "Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche", Nature, 580(7804) :524-529 [PubMed].
2020, "Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.", PLoS One, 15(4) :e0226050 [PubMed].
2020, "ATX expression from GFAP+ cells is essential for embryonic development", bioRxiv, , Jan 17, 2020. doi: 10.1101/2020.01.17.910141 [bioRxiv].
2020, "Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme", Bioorg Med Chem. , Jan 15; 28(2):115216. [PubMed].
2019
2019, "Orotracheal treprostinil administration attenuates bleomycin induced lung injury, vascular remodeling, and fibrosis in mice", Pulm Circ. , 2019 Nov 15; 9(4):204589401988195 [PubMed].
2019, "Deregulated Lysophosphatidic Acid Metabolism and Signalling in Liver Cancer", Cancers, 2019 Oct 23; 11(11). pii: E1626 [PubMed].
2019, "Pulmonary Fibrosis", Frontiers Media SA. [Google Books].
2019, "Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis", Am J Physiol Lung Cell Mol Physiol, 2019 Sep 4 [PubMed].
2019, "Autotaxin and chronic inflammatory diseases", J Autoimmun., 2019 Aug 27: 102327 [PubMed].
2019, "Club cells form lung adenocarcinomas and maintain the alveoli of adult mice", Elife., 2019 May 29. ;8 [PubMed].
2019, "Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials", Med Res Rev., 2019 May; 39(3):976-1013 [PubMed].
2019, "Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis", Pulm Pharmacol Ther, 2019 Apr; 55:17-24. [PubMed].
2018
2018, "Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis", Pulm Pharmacol Ther, 2018 Oct; 52:32-40 [PubMed].
2018, "Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism", J Lipid Res, 2018 Oct; 59(10):1805-1817 [PubMed].
2018, "Bleomycin Revisited: A Direct Comparison of the Intratracheal Micro-Spraying and the Oropharyngeal Aspiration Routes of Bleomycin Administration in Mice", Front Med, 2018 Sep 24; 5:269 [PubMed].
2018, "Autotaxin in Pathophysiology and Pulmonary Fibrosis", Front Med, 2018 Jun 13; 5:180 [PubMed].
2018, "Mesenchymal Stem Cells for the Treatment of Idiopathic Pulmonary Fibrosis", Front Med, 2018 May 15; 5:142 [PubMed].
2018, "The autotaxin - lysophosphatidic acid axis promotes lung carcinogenesis", Cancer Res. , 2018 May 3. pii: canres.3797.2017. doi: 10.1158/0008-5472.CAN-17-3797. [Epub ahead of print] [PubMed].
2018, "Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.", J Med Chem, 2018 Apr 18 [PubMed].
2018, "Metabolic Disorders in Chronic Lung Diseases.", Front Med , 2018 Jan 18; 4:246 [PubMed].
2017
2017, "Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis.", Front Med, 2017 Jul 28; 4:118 [PubMed].
2017, "Biomarkers in Idiopathic Pulmonary Fibrosis: A RAGE-ing Bull in the Arena", Ann Am Thorac Soc., 2017 May; 14(5):613-614 [PubMed].
2017, "Lung cancer in patients with idiopathic pulmonary fibrosis", Pulm Pharmacol Ther., 2017 Apr 1 [PubMed].
2017, "Hepatocyte Autotaxin expression promotes liver fibrosis and cancer", Hepatology, 2017 Apr;65(4):1369-1383. [PubMed].
2017, "Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the 'bed' that counts and not 'the sleepers’", Expert Rev Respir Med, 2017 Mar 8 :1-11. [PubMed].
2017, "SH2 Domain-containing Phosphatase-SHP-2 is a Novel Anti-fibrotic Regulator in Pulmonary Fibrosis", Am J Respir Crit Care Med., 2017 Feb 15; 195(4):500-514. [PubMed].
2017, "Epithelial Myeloid-differentiation Factor 88 is Dispensable During Klebsiella Pneumonia", Am J Respir Cell Mol Biol., 2017 Feb 10. [PubMed].
2017, "Diagnostic and prognostic challenges in Idiopathic Pulmonary Fibrosis A patient "Q and A" approach", Pulm Pharmacol Ther., 2017 Feb; 42:21-24. [PubMed].
2016
2016, "Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.", Curr Med Chem., 2016;23(17) :1708-24 [PubMed].
2016, "Kresoxim-methyl primes Medicago truncatula plants against abiotic stress factors via altered reactive oxygen and nitrogen species signalling leading to downstream transcriptional and metabolic readjustment", J Exp Bot., 2016 Mar; 67(5):1259-74. [PubMed].
2015
2015, "The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life", PLoS One., 2015 Nov 16; 10(11). [PubMed].
2015, "Autotaxin and Endotoxin-Induced Acute Lung Injury", PLoS One. , 2015 Jul 21; 10(7):e0133619 [PubMed].
2015, "Mast cells mediate malignant pleural effusion formation.", J Clin Invest. , 2015 Apr 27. pii: 79840. doi: 10.1172/JCI79840. [Epub ahead of print] [PubMed].
2015, "Non-cell autonomous and non-catalytic activities of ATX in the developing brain", Front Neurosci., 2015 Mar 4; 9:53 [PubMed].
2015, "Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer", Prog Lipid Res., 2015 Feb 20. pii: S0163-7827(15)00011-9. doi: 10.1016/j.plipres.2015.02.001. [Epub ahead of print] [PubMed].
2014
2014, "Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis", Proc Natl Acad Sci U S A. , 2014 Oct 28; 111(43):E4658-67. doi: 10.1073/pnas.1415762111. Epub 2014 Oct 14. [PubMed].
2014, "A biobank for Interstitial Lung Diseases according to the European Network EurIPF and ΒΒΜRI", Pneumon, vol 27(3) 209-213. [PDF].
2013
2013, "Autotaxin and lysophosphatidic acid signalling in lung pathophysiology.", World J Respirol. , 2013 November 28; 3(3): 77-103. [PDF]
2013, "Autotaxin production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.", Am J Respir Crit Care Med. , 2013 Sep 19. [Epub ahead of print] [PubMed]
2013, "Induced expression and functional effects of Aquaporin-1 in human leukocytes in sepsis.", Crit Care. , 2013 Sep 12; 17(5):R199. [PubMed]
2013, "A metabolically-stabilized phosphonate analog of lysophosphatidic Acid attenuates collagen-induced arthritis.", PLoS One. , 2013 Jul 29; 8(7) [PubMed], [PDF].
2012
2013, "Lysoglycerophospholipids in chronic inflammatory disorders: The PLA(2)/LPC and ATX/LPA axes.", Biochim Biophys Acta. , 2013 Jan;1831(1):42-60. Epub 2012 Jul 31 [PubMed].
2012, "Data Mining and Meta-Analysis on DNA Microarray Data.", IJSBBT, 1(3): 1-39 [Article].
2012, "Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis.", Am J Respir Cell Mol Biol, 2012 Nov;47(5):566-74. Epub 2012 Jun 28 [PubMed].
2012, "CreZOO--the European virtual repository of Cre and other targeted conditional driver strains.", Database (Oxford), 2012 Jun 21; 2012:bas029. Print 2012. [PubMed].
2012, "Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.", J Exp Med., 2012 May 7; 209(5):925-33. Epub 2012 Apr 9. [PubMed].
2011
2011, "Modeling pulmonary fibrosis with bleomycin.", Curr Opin Pulm Med., 2011 Sep; 17(5):355-61. [PubMed].
2010
2010, "Research funding. Sustaining the data and bioresource commons.", Science. , 2010 Oct 29; 330(6004):592-3. [PubMed].
2010, "Mouse Resource Browser--a database of mouse databases.", Database (Oxford). , Jul 6 2010, baq010. [PubMed].
2010, "Finding and sharing: new approaches to registries of databases and services for the biomedical sciences..", Database (Oxford) , Jul 6;2010, baq014 [PubMed].
2010, "The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time.", Ann Med. , 2010 Jun 23., 2010 Sep;42(6):426-38 [PubMed].
2010, "TLR7-triggered Immune Response in the Lung Mediates Acute and Long-lasting Suppression of Experimental Asthma.", Am J Respir Crit Care Med. , Jun 1;181(11): , 1207-16 [PubMed].
2010, "ATX expression and LPA signalling are vital for the development of the nervous system.", Dev Biol., Mar 15;339(2) , :451-64 [PubMed].
2009
2009, "Models for financial sustainability of biological databases and resources ", Database (2009), Vol. 2009, , bap017; [PubMed].
,2009, "Global Impairment of CD4+CD25+FOXP3+ T Regulatory Cells in Idiopathic Pulmonary Fibrosis.", Am J Respir Crit Care Med., Apr 2, 179(12):1121-30 [PubMed].
,2009, "The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development.", Mol Cell Biol., 29(10) :, 2762-76 [PubMed].
,2009, "Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.", Respir Res. , Feb 27. 10(1):14.[Epub ahead of print] [Pubmed].
,2009, "A Critical Role for Gelsolin in Ventilator-Induced Lung Injury.", Am J Respir Cell Mol Biol. , 41(4): 426-32 [Pubmed].
,2009, "Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis.", Thorax. , 64(6): 467-75 [Pubmed].
,2008
2008, "Solutions for data integration in functional genomics: a critical assessment and case study.", Brief Bioinform. , 9(6): 532-44 [Pubmed].
,2008, "Radial Basis Function neural networks classification for the recognition of idiopathic pulmonary fibrosis in microscopic images", IEEE Trans Inf Technol Biomed., 12(1): 42-54. [PubMeb].
,2007
2007, "Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.", Ann Rheum Dis., 66 Suppl 3:iii23-8 (Review) [PubMed].
2008, "MUGEN mouse database; Animal models of human immunological diseases.", Nucleic Acids Res., 36 (Database issue) :D1048-54 [Pubmed]
,2007, "Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia-inducible factor-1alpha in disease pathogenesis", Am J Respir Crit Care Med, 176(11) :1108-19 [Pubmed]
,2007, "Integration of mouse phenome data resources", Mamm. Genome., 18(3):157-63., [Pubmed]
,2006
2006, "Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis.", PLoS One, 2006 Dec 27, e108 [PubMed].
,2006, "Operational criteria for selecting a cDNA microarray data normalization algorithm", Oncol. Rep., 15:983-996. [PubMed]
,2005
2005, "Twin expression profiling identifies cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis", PLoS Genetics, (Vol 1(4), e48 [PubMed].
,2005, "The transcriptional landscape of the mammalian genome", Science., Sep 2., 309(5740):1559-63 [PubMed].
,2004
2004, "Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study", Arthritis Res. & Ther., 6 (3), R282-94 [PubMed].
,2003
2003, "Targeting a complex transcriptome: The construction of the mouse full-length cDNA encyclopedia", Genome Res., 13, 1273-89 [PubMed].
,2003, "Functional analysis of an arthritogenic synovial fibroblast", Arthritis Res. & Ther., 5 (3), 140-157 [PubMed].
,Previous
2000, "Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex", J. Immunol., 164 (11), 5826-5832 [PubMed].
,1999, "The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate Recombination Signal Sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2", Mol. Cell. Biol., 19 (10), 6532-6542 [PubMed].
,1998, "The effect of Me+ cofactors at the initial stages of V(D)J recombination", J. Biol. Chem., 273 (26), 16325-16331 [PubMed].
,1995, "Detection of Human-specific anti-La (SSB) antibodies in patients with Rheumatoid Arthritis", J. Autoimm., 8, 959-969 [PubMed].
,1995, "Two immunologically related polypeptides of 72/74 KD specify a novel 70-110S heterogeneous nuclear RNP", Nucleic. Acids. Res., 23 (14), 2742-2753 [PubMed].
,1994, "Anti-5S RNP antibody levels correlate with disease activity in a patient with SLE syndrome", Clin. Exp. Immunol., 95, 385-389 [PubMed].
,1993, "Detection of anti-RO (SSA) antibodies in autoimmune diseases: comparison of five methods", Br. J. Rheum., 32, 449-455 [PubMed].
,1990, "Immunochemical identification of a novel nuclear RNP complex of 70-110S from rat liver", In 'Nuclear structure and function', Ed. I. B. Zbarsky and J. R. Harris, Plenum Press, New York, 265-272.
,