Drosophila Contributions towards Understanding Neurofibromatosis type 1.
Skoulakis' lab published a critical review summarizing the contributions of Drosophila in modeling multiple manifestations of Neurofibromatosis Type 1 (NF1) and in pharmaceutical approaches to ameliorate them. NF1 results from mutations in Neurofibromin (Nf1), a regulatory protein in multiple cellular processes. Based on phenotypic and molecular analyses of Drosophila Nf1 mutants this review develops hypotheses regarding cell type-specific functions of the protein and explores their pertinence to human disease manifestations towards personalized ameliorative approaches in patients.
Atsoniou, K., Giannopoulou, E., Georganta, E. M., & Skoulakis, E. M. C. (2024). Drosophila Contributions towards Understanding Neurofibromatosis 1. Cells, 13(8), 721. https://doi.org/10.3390/cells13080721