Tau aggregates maybe not be so bad after all!
The results of a new study (pub, Feature) provide surprising evidence of the role of Tau aggregates, though to drive neurodegeneration and cognitive decline, as a protective rather than detrimental, preserving and promoting protein synthesis-dependent memories, whereas soluble Tau appears insidious, disrupting learning and memory.
Large human Tau aggregates in Drosophila CNS (1) protect memory, while preventing their formation resulting in small soluble particles (2), inhibits learning and memory.