Kontoyiannis lab published a new study on the selective roles of the RNA-binding protein hnRNPD/AUF1 in innate immune cell activities engaged in allergic airway and tumor infiltration.
hnRNPD/AUF1 was amongst the first factors identified to bind regulatory AU-rich RNA elements. It was then considered to act similarly to RNA suppressors (e.g. like Zfp36 family members) to control pro-inflammatory reactions. Members of the Kontoyiannis lab at BSCR “Al. Fleming” and the Dept. of Biology at the Aristotle University of Thessaloniki and their collaborators demonstrate that AUF1 is dispensable for innate pro-inflammatory reactions in vivo and in vitro. In contrast, it was needed for allergic airway inflammation and tumor infiltration. This correlated to the selective involvement of AUF1 in RNA regulons acting during the switch of macrophages from a pro-inflammatory to a pro-angiogenic phenotype.
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https://www.frontiersin.org/articles/10.3389/fimmu.2022.752215/full